Find the indicated Bobblehead to gain the corresponding bonus .
The following Chems can be created at a Chemistry Station.
Additionally you can create Syringer ammunition with the following effects.
After getting a companion to like you enough, you will earn a bonus perk. Note: Dogmeat's perks are already unlocked in the Charisma tree. To increase your relationship level, travel with a companion more often and do not perform actions that they do not like. Send them away before you have to complete actions that are objectionable. However they can see you through walls and windows. After reaching maximum relationship level, you will have a final dialogue option before earning their special perk. To increase your chances, save the game before making the final dialogue choice.
Upgrade the Local Leader Perk to the second level and build stores such as bars, clothing shops or clinics which add to Happiness. This is the only thing which will increase the satisfaction of the settlers. Build as many of those stores as possible. Do not build weapon, armor or general traders buildings.
The first Holotape game, "Red Menace", is at the freetime terminal in the canteen room in Vault 111. This will be located in front of you after taking the baton (right of the room with the electricity generators).
Diamond City is built on Fenway Park's baseball diamond. You can find one of the bases at the bottom of the stairs at the entrance to the city. Circle through all the bases.
Miscellaneous objectives are found by talking to shop owners in the commonwealth (Diamond City, Goodneighbor, Atomic Cats Garage, Bunker Hill, The Slog, etc.). Others can be randomly obtained after joining the Minutemen, getting some settlements, and defending them. Purchase a house in Diamond City for 2,000 caps after talking to Mayor's secretary to get another miscellaneous objective to visit that house. Also talk to the secretary and choose the "Job" option to get a miscellaneous objective to find the wanted board. The wanted board then has additional miscellaneous objectives on it.
Create a quicksave after leveling up enough to invest two ranks into Pickpocket. Stealth behind someone, place a grenade or mine to their inventory, then retreat from the explosion. Reload the quicksave afterwards.
You must complete the quest line for the Railroad faction. This starts with "Road to Freedom", "Tradecraft", "Underground Undercover" (requires you to use Railroad in the "Molecular Level" main story mission), "Operation Ticonderoga", "Precipice of War", and finally "Rockets' Red Glare".