Deadpool

Take the sai and use the highest difficulty setting. Start the first level. As soon the first enemies spawn, run further into the room and ignore the enemies that initially run towards you. This will force more enemies to spawn. Run to the back of the large lobby room to fight enemies that spawned earlier. There will still be a steady supply of enemies spawning. While building combos, go towards the section that connects the lobby you are in, to the other big room. When your enemies start declining, there will be another two in on the way that help you reach a 300x-combo.

Use the oven in Deadpool's kitchen.
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This can be done during a second playthrough with all the upgrades. Use the Plasma gun counter to almost instantly kill every enemy. Use the sub machine gun against ranged enemies. For the final Boss battle, use the flashbang grenade and hammer combination. Note: This must be timed correctly to avoid getting grabbed.

Interact with the following objects in Deadpool's apartment.

• The brown chair available as soon as you are in control of Deadpool that can be used to watch TV.
• The phone next to Deadpool's recliner.
• The dog behind the recliner.
• The radio in the left corner next to the neon sign.
• The old softa to the right of the chair.
• The bookcase behind the sofa.
• The toilet in the bathroom to the left of the kitchen door.
• The sink in the bathroom.
• The refrigerator in the kitchen.
• The open pizza box in the lit corner to the right of the door.
• The oven to the right of the pizza box.
• The pump to the left of the bedroom door.
• The computer to the right of the pump.
• The arsenal on the right wall.

Enter the audio options and set "Dialog Volume" to "Mute".