Build any type of power plant, a Stadium (Modern Times required), then issue the "Host the Olympics" edict.
You cannot declare your independence. Do this early, while still a colony. Complete missions to earn mandate extensions until "Everlasting Colony" is earned.
Begin a sandbox game with unlimited money under the easy difficulty setting in the Modern Era. Build the maximum number of Science Labs, Colleges, and Observatories then fully staff them. Search for Inventors in your population by using the "Census" edict. You can also use your Spy Academy to steal technology from other superpowers, but this may not be reliable. Build Power Plants to provide enough power to the Science Lab.
Construct five Embassies and invite all foreign powers to each one. Note: This can be paired with the "For Science!" achievement or trophy.
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Faction leaders can be found through the game menu or by browsing your city. They will have a blue square above their heads. Select "Bribe". The amount of money required will depend on how much influence the leader has and the weight of the faction.
Uprisings occur when your people are dissatisfied. Have a low approval rate, low happiness, and a constitution not in line with the majority. Killing faction leaders will speed the process. To survive an uprising, several army bases and barracks will be needed. Upgrade them if possible. Make sure you have high loyalty with your army. High wages will help accomplish this. Note: This can be earned with "Think tank".
Some of your family members may be helpful. The easiest way to gain managers is to issue the "Census" edict. It will find managing skills among ordinary citizens and can easily result in fifteen managers over time.
Select the icon to access to your family on the lower bar. Choose family member then change his or her appearance.
Consider doing this over five missions due to the cooldown for each upgrade of a family member. Access your family by using the icon in the lower bar. Select a family member, then select "Upgrade". The upgrades will cost $10,000, $20,000, $30,000, and $40,000 from your Swiss bank account funds.
Family members will appear occasionally during missions. For example, you may get the event "Presidente cheated on his wife, you can either choose to recognize a new heir or not". The first option will add a member to your family. You should be able to add seven new family members by the end of the main campaign.