Resident Evil

When you have drained the water and are about to get the Gallery Key, Neptune will start to get a bit rowdy and you will have to kill him. Instead of wasting precious ammunition, push the electrical box into the water. Neptune will not do anything. Then, walk to the generator and pull the lever. Neptune should get electrocuted and die. Get the Gallery Key that is next to him and leave the area.
ATX-03027911 and clay boger.

To kill Plant 42 without the V-Jolt, use the grenade launcher glitch with the flame rounds. Shoot it about six times.
Sleepyhead1092.

To defeat Plant 42 as Chris under the easy or normal difficulty settings, first run around the room. Equip the assault shotgun or shotgun and fire up only when you hear the plant's pedals open. Once they are open, aim up and fire away. When the pedals close, run around the room to avoid any damage. Continue this process until the plant falls. You should need close to twenty rounds or less and some health items. Remember, a little ammunition or health is never enough.
Bubba.

Instead of running all around the mansion looking for the chemicals, just use Grenade Launcher Incendiary rounds, or try a hit-and-run strategy with the knife.
Andrew Keith.

Use the following strategy when fighting Tyrant on the helipad. You do not need the Magnum, as both the handgun and shotgun work equally well. Brad will always throw you the rocket launcher at about 1:38 on the timer, regardless of what weapon you are using. Keep tyrant in the same camera view as you. Get as far away as you can without changing the camera angle. Keep your distance and shoot with whatever you are carrying until Tyrant stands still and/or begins shuddering. Once Tyrant does this, stop firing and wait. Tyrant will charge at you. To avoid damage, run to Tyrant's right once he starts running. Tyrant's claw arm is the only arm he will use when he charges, and that is on his left side. If you run to Tyrants right (the side with his "normal" arm), you can avoid the attack, get your distance, and begin firing again. When the timer reaches about 1:38, Brad will throw you the rocket launcher. Quickly grab it and put some distance between yourself and Tyrant. The first rocket launcher shot will generally be deflected, and if he is close, Tyrant will slash you while you are lifting the weapon again. Fire the second shot to end the battle.
kyle.sm.