Resident Evil 4

In chapter 5-3, right before the room with the lasers, there's a red throne room. Approach the throne and hit 'A' to have Leon sit upon the throne in all his glory.

After the end credits there is a short radio conversation between Leon and Hunnigan. Leon will notice Hunnigan is no longer wearing her glasses and will actually try to hit on her.

When Ashley is following you find something somewhat high off of the ground and climb on top. Then tell Ashley to stay put. Go below where you left Ashley standing. When you are underneath and you try to move the C-Stick up to look at Ashley, she will ask Leon what is he looking at and call him a pervert.

In Chapter 1-1, along the path towards the village you will run along a white dog trapped in a bear trap. If you help this dog he comes in handy later when you are fighting Los Gigante for the first time. About midway through the fight, you will hear the dog bark and he will come to your aid. Los Gigante becomes distracted, and begins to attack the dog rather than you.

In the area you fight him there is a yellow herb you can use with a green herb to increase your health. Grab it and use it to increase your health then let him kill you, which won't be that hard. After your game is over continue and you will have all of your green herbs again and the extra health. The yellow herb will be out there again so grab it and repeat the process increasing your health over and over again till its maxed out fairly early in the game.

Beat the game to unlock the mercenaries mini game.

When running around different areas of the village, you will see crows. Pick them off from a distance as to not scare the others away. They usually drop Pesetas. If you scare some away, just re-enter the area to reset their position.

When you find these items do not sell them right away. You can increase the value of the items with gems.

Tap A(2) when the "Open" action appears to kick open or down some doors instead of nudging them by hand. This will give you an advantage, as any enemies behind the door will be sent flying back.

There are many locks on doors. Instead of shooting the locks and wasting ammunition, pull out your knife and cut it off. The same can be done for boxes.