Gun

Defeat Hollister to unlock the .69 Ferguson Rifle.

Complete the following achievements to unlock Xbox Live Gamerscore points.

Take a barrel of TNT from the Badlands mine. Find the abandoned house in the Badlands where the buffalo graze. Go to the back of the house on the outside. Face the chimney (looking west) and place the TNT barrel on the left side of the chimney. Blow up the TNT barrel to open a hole in the ground with ammunition for all weapons. The ammunition will reappear over time after you leave the area.

If any of these animals are not there, look around the surrounding area. If they still do not appear, go to the farthest away town (Empire or Dodge) and return.

Gray Wolf: Near the bridge in Dodge.
White Buffalo: Near the mine (not Magruder's). It roams with the other buffalo.
White Wolf: Near Piper lake, usually by the waterfall.
Mountain Lion: Go to where Magruder's mine is located. Stand at it with your back to it. To your left is the train tunnel, and to your right is the path to the Indian hunter. Go through the middle path and it should be through there.
Great Wolf: Same place the White Buffalo was, usually behind the mine.
Grizzly: Near Empire.The map will show you its location. You do not have to use an arrow to kill him.

Successfully complete the Hunting missions to unlock the Apache shirt.

Successfully complete Story mode to unlock Magruder's seven barrel Nock gun. Successfully complete Story mode and all side missions (100% completion) to unlock Reed's armored horse and Magruder's Cannon Nock gun.

After talking to Soapy, run to front of train towards the water. Leave your horse behind the rock near the bridge. Run back to the engine of the train and stay in front. Wait for the two riders to come through. Use your quick draw to take them out. Take their horses and leave them with your horse. Take cover in front of the engine again. Two more riders will appear. You can see them riding quickly around the train on your map. Use the same method. Then, go to one of the horses and ride him around the rock towards the cannon. Use quick draw to take out the two men on either side of Dutchie. Your horse will probably die and you will have to take a shot or perhaps two, but keep moving towards the back of the train and into tunnel until you find cover behind it. Sneak around to the right on the same side you started on. Kill the man on top of the car first, then the man standing by the rail on the same car. Next, squeeze between the two cars and aim directly for the end of the cannon with whatever weapon desired. Shoot Dutchie until he is dead.
Atomictoothpick

Take out Duchie first. Use Ned's rifle and just keep shooting at Duchie. Keep moving to avoid as much damage as possible. Stay on your horse as long as you can. Once your horse has been killed do not take another until Duchie has been defeated. By this time all side missions should be unlocked. Do all of them as it will not only make fighting Duchie easier but it will also make completing the rest of the game a lot easier.
Jaycie Marisa Loud

Talk to Soapy then get your horse and ride back up the mountain. At the part just before the TNT, get off your horse. Walk out on the ledge. Keep walking and to reach a location where he cannot hit you. From here you can snipe him, shoot him in the head with fire arrows. The fire arrows will keep wearing down his health, even though it does not have the stopping power. After this, you still have to take care of the riders. Get back on your horse and use your Quickdraw. It helps if you get your stats up by doing the Bounty Hunting or Wanted Poster side missions. Make sure that you hit the riders, not their horses. They will shoot at your horse, and you can use their horse as a replacement ifneeded. The double barrel shotgun is recommended because they stand close together and it can take out more than one enemy.

Defeating Dutchie
After talking to Soapy, run to front of train towards the water. Leave your horse behind the rock near the bridge. Run back to the engine of the train and stay in front. Wait for the two riders to come through. Use your quick draw to take them out. Take their horses and leave them with your horse. Take cover in front of the engine again. Two more riders will appear. You can see them riding quickly around the train on your map. Use the same method. Then, go to one of the horses and ride him around the rock towards the cannon. Use quick draw to take out the two men on either side of Dutchie. Your horse will probably die and you will have to take a shot or perhaps two, but keep moving towards the back of the train and into tunnel until you find cover behind it. Sneak around to the right on the same side you started on. Kill the man on top of the car first, then the man standing by the rail on the same car. Next, squeeze between the two cars and aim directly for the end of the cannon with whatever weapon desired. Shoot Dutchie until he is dead.

Take out Duchie first. Use Ned's rifle and just keep shooting at Duchie. Keep moving to avoid as much damage as possible. Stay on your horse as long as you can. Once your horse has been killed do not take another until Duchie has been defeated. By this time all side missions should be unlocked. Do all of them as it will not only make fighting Duchie easier but it will also make completing the rest of the game a lot easier.

Talk to Soapy then get your horse and ride back up the mountain. At the part just before the TNT, get off your horse. Walk out on the ledge. Keep walking and to reach a location where he cannot hit you. From here you can snipe him, shoot him in the head with fire arrows. The fire arrows will keep wearing down his health, even though it does not have the stopping power. After this, you still have to take care of the riders. Get back on your horse and use your Quickdraw. It helps if you get your stats up by doing the Bounty Hunting or Wanted Poster side missions. Make sure that you hit the riders, not their horses. They will shoot at your horse, and you can use their horse as a replacement ifneeded. The double barrel shotgun is recommended because they stand close together and it can take out more than one enemy.

Sneak up on him and shoot him once. Then, run off and get behind a rock on top of risen ground in the middle of the arena. When he is circling the rock your are behind, you should also circle as well. He will eventually stop and yell at you to come out. He should pace back and forth slowly while you hide behind your rock. When he stops and is not facing you, shoot him in the head. Perform this until the point that he becomes too smart to fall for it again. By then his health should be low enough so that you can run out and keep shooting while strafing. After you have gotten his health down all the way there will be a intermission sequence. Look at your compass at the bottom of the screen. He is the red dot. Find him and he will run at you. Run, but keep firing at him with your pistols and he will blow up

Use Quickdraw with your Dual Peacemakers and he will explode.

When you start this mission, you will be looking at the Indians and Soapy. Start going to the right. All the way to the right is a ramp-like hill. Go up it a short distance. He will first throw TNT, then will just stand there and not do anything. When you are in a crouched position, start shooting him and he will not move. Until his health is all the way down and it will go to the next part of the mission where you must blow him up.

Sneak up on Hollister and shoot him in the head. Then, run to the boat by Soapy and the Indian and hide behind the rudder. Face Soapy and the Indian. If done correctly, Hollister will not be able to shoot you before you shoot him. Hollister will try to walk around the boat to find you, and you can keep shooting him in the head every time he comes into view. Once shot, he will back off. After a few seconds he will try again, Keep shooting and you will defeat him easily.

It would help if you have purchased the shotgun speed loader, extra shotgun ammunition capacity, and the extra health slot upgrades. When you start the fight. Hollister knows where you are. Sneak up into the rocks. He will not know where you are until you reveal yourself for the first time. Once you do, he will know where you are for the rest of the fight. Keeping that in mind, sneak up on him without being seen with your shotgun equipped and fully loaded. Once you are behind him, get as close as you can without being seen, as shotguns do the most damage when up close. Then, just fire away with your shotgun as fast as possible. Do not forget to drink your whiskey when your health gets low. Note: This works under the normal and easy difficulty settings with no shotgun upgrades purchased.

It is not possible to kill Magruder by shooting him, as he is wearing armored plating. Instead, use the bow with exploding arrows. Get Magruder to chase you. As you are backing away from him, shoot an arrow at a geyser as he walks over it. The flammable gas coming from the geyser will explode and damage Magruder until he is almost dead. Then, when he is on the higher level, shoot him in the face with the rifle until he yells, then get into Quickdraw mode. Get ready to shoot the big package of dynamite when he throws it. After shooting a few sticks of dynamite, the roof will collapse on him.

Never let Reed out of your sight. If he is by himself and you cannot see him, he gains life.

This is very difficult at first. Before you start the mission, go back to Empire City and Dodge City and get as many weapon upgrades as possible. Do about 60 to 70 percent of the side missions beforehand. Use the upgrades for mostly the rifle and bow, and the health upgrade for your horse. Once you bring these stats up, go to the mission and defeat Hollister again. Then, defeat Magruder's riders. Once that is done, open the safe and Reed will show up. You will start behind a rock. Take out the newly acquired rifle obtained from Hollister, get on the horse to the left, and chase after him. Keep shooting him. It will take about three minutes to kill him. Do not lose sight of him, or his health will go up.

Use the bow and arrows. Make sure you are full up on whiskey. When you hit him with the first arrow, he will not run. He will continue to fire at you, though not nearly as often. Just launch one arrow after another (several are required) until you drain his life and he falls off the horse.

Corner Reed while he is on his horse. Quickly get of your horse, then run up and start using the melee. Make sure to heal and he will die quickly.

Make sure that you are full on whisky and shotgun ammunition. Stay behind Reed and aim for his head with the double-barreled shotgun.