Find the indicated Bobblehead to gain the corresponding bonus .
The following Chems can be created at a Chemistry Station.
Additionally you can create Syringer ammunition with the following effects.
After getting a companion to like you enough, you will earn a bonus perk. Note: Dogmeat's perks are already unlocked in the Charisma tree. To increase your relationship level, travel with a companion more often and do not perform actions that they do not like. Send them away before you have to complete actions that are objectionable. However they can see you through walls and windows. After reaching maximum relationship level, you will have a final dialogue option before earning their special perk. To increase your chances, save the game before making the final dialogue choice.
Upgrade the Local Leader Perk to the second level and build stores such as bars, clothing shops or clinics which add to Happiness. This is the only thing which will increase the satisfaction of the settlers. Build as many of those stores as possible. Do not build weapon, armor or general traders buildings.
The first Holotape game, "Red Menace", is at the freetime terminal in the canteen room in Vault 111. This will be located in front of you after taking the baton (right of the room with the electricity generators).